The main scientific objectives of the programme will be addressed by the research activities broken down into the 2 subprogrammes cited above: 1) Molecular mechanisms; 2) Target discovery and Pre-clinical models. Each of these subprogrammes will contain different subprojects which align to the ESR and ER projects that will be undertaken by the researchers involved. Each subprogramme has a leading participant that will supervise the execution of the tasks. Partners will alternate in organizing network meetings which will include laboratory courses, single-topic conferences and network workshops, as well as secondments and visits to other centres. Synergies and collaborations are specifically indicated in each case.